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生物医学工程研究所

  • 姓 名:

    梅林

  • 单 位:

    中国医学科学院生物医学工程研究所

  • 教职岗位:

    长聘副教授

  • 聘任时间:

    2022-03-01

  • 一级学科:

    药学

  • 二级学科:

    药剂学

  • 联系方式:

    meilin@bme.pumc.edu.cn

  • 导师风采链接:
    https://yzbss.pumc.edu.cn/basicinfo/tutorinfo/tutordetail/J2020150002

个人简介

梅林,教授、博导,天津市生物医学材料重点实验室主任。2003年获复旦大学药学学士,2007年获北京协和医学院生物医学工程博士。作为第一完成人,获天津市自然科学奖二等奖、深圳市自然科学奖二等奖、中华医学科技奖、深圳市青年科技奖。2021年起入选全球高被引科学家、国家健康科普专家,获国家优秀青年科学基金等资助。 腾博会游戏大厅_竞彩足球-官网:引进人才,2022年加入腾博会游戏大厅_竞彩足球-官网:,此前任中山大学“百人计划”教授、清华大学深圳国际研究生院副教授、清华博士后、新加坡国立大学博士后。


主要研究内容

长期从事药物载体材料和先进递释系统研究;承担国家重点研发计划课题等20余项国家和省部级科研课题,在Science Translational Medicine等杂志发表论文100余篇,H指数70,4次入选高被引科学家。主编专著1部,参编3部。培养博士、硕士、博士后30余名。担任Smart Materials in Medicine和VIEW副主编,Journal of Controlled Release、Asian Journal of Pharmaceutical Sciences和Chinese Chemical Letters编委。


代表性成果

腾博会游戏大厅_竞彩足球-官网

图片

1.Lu S, Shi Z, Ding C, Wang W, Zhang W, Huang L, Lin J, Wang X, Luo R, Zeng X, Zhou W, Chen H*, Wang Q*, Mei L*. BRD4-targeted photodegradation nanoplatform for light activatable melanoma therapy. Biomaterials. 2025, 317:123101.

2.Yunfei Yi, Zhangwen Peng, Yuanqi Liu, Huisong Hao, Liu Yu, Simin Wen, Shengjie Sun, Jianlin Shi*, Meiying Wu*, Lin Mei*. siRNA micelleplexes-mediated glutamine metabolism re-engineering for vascular normalization-boosted photo-immunotherapy. Acta Pharm Sin B. 2025, 15(4):2237-2252.

3.Sheng S, Zhang Y, Jin L, Sun W, Zhu D, Mei L*, Dong X*, Lv F*. A ferritin-targeted biohybrid triggering ferroptosis immunotherapy via activating endogenous iron and replenishing exogenous iron simultaneously. Nat Commun. 2025 Jul 1;16(1):6045.

4.Zhang H, Zhang Y, Zhang Y, Li H, Ou M, Yu Y, Zhang F, Yin H, Mao Z*, Mei L*. Catalytic activity of violet phosphorus-based nanosystems and the role of metabolites in tumor therapy. Nat Commun. 2024, 15(1):6783.

5.Yu Y, Li T, Ou M, Luo R, Chen H, Ren H, Li Z, Sun J, Zhang H, Peng S, Zhao Y, Mei L*.  OX40L-expressing M1-like macrophage exosomes for cancer immunotherapy. J Control Release. 2024;365:469-479. (ESI)

6.Yu Y, Zhang F, Xiao W, Cheng Q, Li T, Tang J, Tao W, Mei L*. Adaptive Design of Nanovesicles Overcoming Immunotherapeutic Limitations of Chemotherapeutic Drugs through Poliovirus Receptor Blockade. ACS Nano 2024, 18(7): 5915–5929.

7.Shi Z, Luo M, Huang Q, Ding C, Wang W, Wu Y, Luo J, Lin C, Chen T, Zeng X, Mei L*, Zhao Y*, Chen H*. NIR-dye bridged human serum albumin reassemblies for effective photothermal therapy of tumor. Nat Commun. 2023;14(1):6567.

8.Yongkang Yu#, Qinzhen Cheng#, Xiaoyuan Ji, Hongzhong Chen, Wenfeng Zeng, Xiaowei Zeng*, Yanli Zhao*, Lin Mei*. Engineered drug-loaded cellular membrane nanovesicles for efficient treatment of postsurgical cancer recurrence and metastasis. Science Advances, 2022, 8(49): eadd3599. (ESI, C100)

9.Zeng W, Yu M, Chen T, Liu Y, Yi Y, Huang C, Tang J, Li H, Ou M, Wang T, Wu M*, Mei L*. Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy. Adv Sci. 2022, 9(23):2201703. (ESI, C100

10.Chen T, Zeng WW, Tie CJ, Yu M, Hao HS, Deng Y, Li QQ, Zheng HR*, Wu MY*, Mei L*. Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics. Bioactive Materials 2022;10:515-525. (ESI, C100)

11.Lin YX#, Wang Y#, Ding JX, Jiang AP, Wang J, Yu M, Blake S, Liu SS, Bieberich CJ, Farokhzad OC*, Mei L*, Wang H*, Shi JJ*. Tumor suppressor reactivation by mRNA nanoparticles induces anti-tumor immunity and improves immune checkpoint blockade therapy. Science Translational Medicine 2021;599(13):eaba9772.(ESI, F100, C100)

12.Zhang F, Lu G, Wen X, Li F, Ji X, Li Q, Wu M, Cheng Q, Yu Y, Tang J, Mei L*. Magnetic nanoparticles coated with polyphenols for spatio-temporally controlled cancer photothermal/ immunotherapy. J Control Release. 2020;326:131-139. (ESI, C100

13.Ye Xinyu, Liang Xin, Chen Qian, Miao Qianwei, Chen Xiuli, Zhang Xudong*, Mei Lin*. Surgical Tumor-Derived Personalized Photothermal Vaccine Formulation for Cancer Immunotherapy. ACS Nano 2019;13(3);2956-2968. (ESI, C100)

14.Zeng X#, Luo M#, Liu G#, Wang XS, Tao W, Lin Y, Ji XY, Nie L, Mei L*. Polydopamine-modified black phosphorous nanocapsule with enhanced stability and photothermal performance for tumor multimodal treatments. Advanced Science 2018, 5(10): 1800510. (ESI, C100)

15.Tao W#, Zhu X#, Yu X#, Zeng X, Xiao Q, Zhang X, Ji X, Wang X, Shi J*, Zhang H*, Mei L*. Black phosphorus nanosheets as a robust delivery platform for cancer theranostics. Advanced Materials., 2017; 29 (1): 1603276.(ESI, C100)